The Ecosystem Services Benchmark

The impacts and dependences of companies on natural resources is a key factor for their future performance. The new Ecosystem Services Benchmark identifies risks and performances of companies and provides a strategic framework on the issue, often overlooked in established management systems

An Empirical Study of the I2P Anonymity Network and its Censorship Resistance

Tor and I2P are well-known anonymity networks used by many individuals to protect their online privacy and anonymity. Tor's centralized directory services facilitate the understanding of the Tor network, as well as the measurement and visualization of its structure through the Tor Metrics project. In contrast, I2P does not rely on centralized directory servers, and thus obtaining a complete view of the network is challenging. In this work, we conduct an empirical study of the I2P network, in which we measure properties including population, churn rate, router type, and the geographic distribution of I2P peers. We find that there are currently around 32K active I2P peers in the network on a daily basis. Of these peers, 14K are located behind NAT or firewalls. Using the collected network data, we examine the blocking resistance of I2P against a censor that wants to prevent access to I2P using address-based blocking techniques. Despite the decentralized characteristics of I2P, we discover that a censor can block more than 95% of peer IP addresses known by a stable I2P client by operating only 10 routers in the network. This amounts to severe network impairment: a blocking rate of more than 70% is enough to cause significant latency in web browsing activities, while blocking more than 90% of peer IP addresses can make the network unusable. Finally, we discuss the security consequences of the network being blocked, and directions for potential approaches to make I2P more resistant to blocking.Comment: 14 pages, To appear in the 2018 Internet Measurement Conference (IMC'18

Aligning evidence generation and use across health, development, and environment

© 2019 The Authors Although health, development, and environment challenges are interconnected, evidence remains fractured across sectors due to methodological and conceptual differences in research and practice. Aligned methods are needed to support Sustainable Development Goal advances and similar agendas. The Bridge Collaborative, an emergent research-practice collaboration, presents principles and recommendations that help harmonize methods for evidence generation and use. Recommendations were generated in the context of designing and evaluating evidence of impact for interventions related to five global challenges (stabilizing the global climate, making food production sustainable, decreasing air pollution and respiratory disease, improving sanitation and water security, and solving hunger and malnutrition) and serve as a starting point for further iteration and testing in a broader set of contexts and disciplines. We adopted six principles and emphasize three methodological recommendations: (1) creation of compatible results chains, (2) consideration of all relevant types of evidence, and (3) evaluation of strength of evidence using a unified rubric. We provide detailed suggestions for how these recommendations can be applied in practice, streamlining efforts to apply multi-objective approaches and/or synthesize evidence in multidisciplinary or transdisciplinary teams. These recommendations advance the necessary process of reconciling existing evidence standards in health, development, and environment, and initiate a common basis for integrated evidence generation and use in research, practice, and policy design

Genotyping of Toxoplasma gondii by Multiplex PCR and Peptide-Based Serological Testing of Samples from Infants in Poland Diagnosed with Congenital Toxoplasmosis

Toxoplasma gondii has a clonal population genetic structure with three (I, II, and III) lineages that predominate in North America and Europe. Type II strains cause most cases of symptomatic human infections in France and the United States, although few other regions have been adequately sampled. Here we determined the parasite genotype in amniotic fluid and cerebrospinal fluid samples from congenital toxoplasmosis cases in Poland. Nineteen confirmed congenital cases of toxoplasmosis were analyzed, including both severe and asymptomatic cases. The genotype of parasite strains causing congenital infection was determined by direct PCR amplification and restriction fragment length polymorphism analysis. Nested multiplex PCR analysis was used to type four independent polymorphic markers. The sensitivity of multiplex nested PCR was ≥25 parasites/ml in amniotic fluid and cerebral spinal fluid samples. Parasite DNA was successfully amplified in 9 of 19 samples (eight severely affected and one asymptomatic fetus). Only genotype II parasites were identified as the source of T. gondii infection based on restriction fragment length polymorphism analysis. Strains causing congenital infections were also typed indirectly based on detection of antibodies to strain-specific peptides. Serotyping indicated that 12 of 15 cases tested were caused by type II strains and these positives included both symptomatic and asymptomatic infections. Overall, the combined analysis indicated that 14 of the cases were caused by type II strains. Our results are consistent with the hypothesis that parasite burden is associated with severity of congenital toxoplasmosis and indicate that serological testing provides a promising method for genotypic analysis of toxoplasmosis

Percolating transport in superconducting nanoparticle films

© 2017 Author(s). Nanostructured and disordered superconductors exhibit many exotic fundamental phenomena, and also have many possible applications. We show here that films of superconducting lead nanoparticles with a wide range of particle coverages, exhibit non-linear V(I) characteristics that are consistent with percolation theory. Specifically, it is found that V (I-Ic)a, where a = 2.1 ± 0.2, independent of both temperature and particle coverage, and that the measured critical currents (I c ) are also consistent with percolation models. For samples with low normal state resistances, this behaviour is observable only in pulsed current measurements, which suppress heating effects. We show that the present results are not explained by vortex unbinding [Berezinskii-Kosterlitz-Thouless] physics, which is expected in such samples, but which gives rise to a different power law behaviour. Finally, we compare our results to previous calculations and simulations, and conclude that further theoretical developments are required to explain the high level of consistency in the measured exponents a.status: publishe

Solventless Lactam Synthesis by Intramolecular Cyclizations of α-Iminoester Derivatives under Microwave Irradiation

We have previously reported a new synthesis of amides from esters and amines under microwave irradiation, offering much higher yields than those achieved with conventional heating [1]. We have now extended these studies to the ring closure of neat iminoesters I2, I3 and I4-I6 to give five- and six-membered ring lactams L5, L6 and larger lactams L7-L9 (where I means imine and L means lactam), respectively, under both classical heating conditions and microwave irradiation